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Int Urol Nephrol. 2013 Oct;45(5):1527-32. doi: 10.1007/s11255-012-0238-5. Epub 2012 Jul 24.

Recurrence of fibrillary glomerulonephritis in a renal transplant recipient.

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  • 1King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, amituualli@ksu.edu.sa.

Abstract

Fibrillary glomerulonephritis (FGN) is a rare glomerular deposition disease and a rare cause of nephrotic syndrome. The patients usually present with renal insufficiency, nephrotic range proteinuria and microscopic hematuria. The electron microscopy study is the only means of diagnosis. The clinical course of the disease is generally unpredictive and the patients inevitably progress to ESRD. Here, we describe a case of FGN, which presented with nephrotic syndrome and impaired renal function. Renal biopsy showed that 26 out of 30 glomeruli were completely sclerosed. Remaining showed mesangial expansion and double contour consistent with a membranoproliferative pattern, with 70 % interstitial fibrosis and tubular atrophy. Immunofluorescence revealed C3 (2+) diffuse mesangial deposits. Electron microscopic showed subendothelial dense deposits with organized tubular structures. During follow-up, the patient underwent renal transplantation from a living unrelated kidney donor. Later on, as the renal allograft function showed deterioration, renal biopsy was performed and showed recurrence of FGN in the renal allograft.

PMID:
22826142
[PubMed - indexed for MEDLINE]
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