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Stat Med. 2012 Dec 30;31(30):4296-308. doi: 10.1002/sim.5516. Epub 2012 Jul 24.

Two-stage meta-analysis of survival data from individual participants using percentile ratios.

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  • 1MRC Biostatistics Unit, Cambridge, UK. Jessica.Barrett@mrc-bsu.cam.ac.uk


Methods for individual participant data meta-analysis of survival outcomes commonly focus on the hazard ratio as a measure of treatment effect. Recently, Siannis et al. (2010, Statistics in Medicine 29:3030-3045) proposed the use of percentile ratios as an alternative to hazard ratios. We describe a novel two-stage method for the meta-analysis of percentile ratios that avoids distributional assumptions at the study level.

Copyright © 2012 John Wiley & Sons, Ltd.

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