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Int J Epidemiol. 2012 Oct;41(5):1419-33. doi: 10.1093/ije/dys086. Epub 2012 Jul 23.

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis.

Collaborators (417)

Wormser D, Di Angelantonio E, Kaptoge S, Wood AM, Gao P, Sun Q, Walldius G, Selmer R, Verschuren WM, Bueno-de-Mesquita HB, Engström G, Ridker PM, Njølstad I, Iso H, Holme I, Giampaoli S, Tunstall-Pedoe H, Gaziano JM, Brunner E, Kee F, Tosetto A, Meisinger C, Brenner H, Ducimetiere P, Whincup PH, Tipping RW, Ford I, Cremer P, Hofman A, Wilhelmsen L, Clarke R, Boer IH, Jukema JW, Ibañez AM, Lawlor DA, D'Agostino RB, Rodriguez B, Casiglia E, Stehouwer CD, Simons LA, Nietert PJ, Barrett-Connor E, Panagiotakos DB, Björkelund C, Strandberg TE, Wassertheil-Smoller S, Blazer DG, Meade TW, Welin L, Svärdsudd K, Woodward M, Nissinen A, Kromhout D, Jørgensen T, Tilvis RS, Guralnik JM, Rosengren A, Taylor JO, Kiechl S, Dagenais GR, Gerry F, Fowkes R, Wallace RB, Khaw KT, Shaffer JA, Visser M, Kauhanen J, Salonen JT, Gallacher J, Ben-Shlomo Y, Kitamura A, Sundström J, Wennberg P, Kiyohara Y, Daimon M, de la Cámara AG, Cooper JA, Onat A, Devereux R, Mukamal KJ, Dankner R, Knuiman MW, Crespo CJ, Gansevoort RT, Goldbourt U, Nordestgaard BG, Shaw JE, Mussolino M, Nakagawa H, Fletcher A, Kuller LH, Gillum RF, Gudnason V, Assmann G, Wald N, Jousilahti PR, Greenland P, Trevisan M, Ulmer H, Butterworth AS, Folsom AR, Davey-Smith G, Hu FB, Danesh J, Tipping RW, Ford CE, Simpson LM, Walldius G, Jungner I, Folsom AR, Demerath EW, Franceschini N, Lutsey PL, Panagiotakos DB, Pitsavos C, Chrysohoou C, Stefanadis C, Shaw JE, Atkins R, Zimmet PZ, Barr EL, Knuiman MW, Whincup PH, Wannamethee SG, Morris RW, Willeit J, Kiechl S, Weger S, Oberhollenzer F, Wald N, Ebrahim S, Lawlor DA, Gallacher J, Ben-Shlomo Y, Yarnell JW, Casiglia E, Tikhonoff V, Greenland P, Shay CM, Garside DB, Nietert PJ, Sutherland SE, Bachman DL, Keil JE, de Boer IH, Kizer JR, Psaty BM, Mukamal KJ, Nordestgaard BG, Tybjærg-Hansen A, Jensen GB, Schnohr P, Giampaoli S, Palmieri L, Panico S, Pilotto L, Vanuzzo D, de la Cámara AG, Simons LA, Simons J, McCallum J, Friedlander Y, Gerry F, Fowkes R, Price JF, Lee AJ, Taylor JO, Guralnik JM, Phillips CL, Wallace RB, Kohout FJ, Cornoni-Huntley JC, Guralnik JM, Blazer DG, Guralnik JM, Phillips CL, Phillips CL, Guralnik JM, Khaw KT, Wareham NJ, Brenner H, Schöttker B, Müller H, Rothenbacher D, Wennberg P, Jansson JH, Nissinen A, Donfrancesco C, Giampaoli S, Woodward M, Vartiainen E, Jousilahti PR, Harald K, Salomaa V, D'Agostino RB, Vasan RS, Fox CS, Pencina MJ, Daimon M, Oizumi T, Kayama T, Kato T, Bladbjerg EM, Jørgensen T, Møller L, Jespersen J, Dankner R, Chetrit A, Lubin F, Svärdsudd K, Eriksson H, Welin L, Lappas G, Rosengren A, Lappas G, Welin L, Svärdsudd K, Eriksson H, Lappas G, Bengtsson C, Lissner L, Björkelund C, Cremer P, Nagel D, Strandberg TE, Salomaa V, Tilvis RS, Miettinen TA, Tilvis RS, Strandberg TE, Kiyohara Y, Arima H, Doi Y, Ninomiya T, Rodriguez B, Dekker JM, Nijpels G, Stehouwer CD, Hu FB, Sun Q, Rimm EB, Willett WC, Iso H, Kitamura A, Yamagishi K, Noda H, Goldbourt U, Vartiainen E, Jousilahti PR, Harald K, Salomaa V, Kauhanen J, Salonen JT, Kurl S, Tuomainen TP, Poppelaars JL, Deeg DJ, Visser M, Meade TW, De Stavola BL, Hedblad B, Nilsson P, Engström G, Verschuren WM, Blokstra A, de Boer IH, Shea SJ, Meisinger C, Thorand B, Koenig W, Döring A, Verschuren WM, Blokstra A, Bueno-de-Mesquita HB, Wilhelmsen L, Rosengren A, Lappas G, Fletcher A, Nitsch D, Kuller LH, Grandits G, Tverdal A, Selmer R, Nystad W, Mussolino M, Gillum RF, Hu FB, Sun Q, Manson JE, Rimm EB, Hankinson SE, Meade TW, De Stavola BL, Cooper JA, Bauer KA, Davidson KW, Kirkland S, Shaffer JA, Shimbo D, Kitamura A, Iso H, Sato S, Holme I, Selmer R, Tverdal A, Nystad W, Nakagawa H, Miura K, Sakurai M, Ducimetiere P, Jouven X, Bakker SJ, Gansevoort RT, van der Harst P, Hillege HL, Crespo CJ, Garcia-Palmieri MR, Kee F, Amouyel P, Arveiler D, Ferrières J, Schulte H, Assmann G, Jukema JW, de Craen AJ, Sattar N, Stott DJ, Cantin B, Lamarche B, Després JP, Dagenais GR, Barrett-Connor E, Bergstrom J, Bettencourt RR, Buisson C, Gudnason V, Aspelund T, Sigurdsson G, Thorsson B, Trevisan M, Hofman A, Ikram MA, Tiemeier H, Witteman JC, Tunstall-Pedoe H, Tavendale R, Lowe GD, Woodward M, Devereux R, Yeh JL, Ali T, Calhoun D, Ben-Shlomo Y, Davey-Smith G, Onat A, Can G, Nakagawa H, Sakurai M, Nakamura K, Morikawa Y, Njølstad I, Mathiesen EB, Løchen ML, Wilsgaard T, Sundström J, Ingelsson E, Michaëlsson K, Cederholm T, Gaziano JM, Buring J, Ridker PM, Gaziano JM, Ridker PM, Ulmer H, Diem G, Concin H, Rodeghiero F, Tosetto A, Wassertheil-Smoller S, Manson JE, Marmot M, Clarke R, Fletcher A, Brunner E, Shipley M, Kivimaki M, Ridker PM, Buring J, Ford I, Robertson M, Ibañez AM, Feskens E, Geleijnse JM, Kromhout D, Walker M, Watson S, Alexander M, Butterworth AS, Franco OH, Gao P, Gobin R, Haycock P, Kaptoge S, Seshasai SR, Lewington S, Pennells L, Rapsomaniki E, Sarwar N, Thompson A, Thompson SG, Walker M, Watson S, White IR, Wood AM, Wormser D, Zhao X, Danesh J.

Author information

  • 1Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.

Abstract

BACKGROUND:

The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.

METHODS:

We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174374 deaths or major non-fatal vascular outcomes recorded among 1085949 people in 121 prospective studies.

RESULTS:

For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.

CONCLUSION:

Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.

Comment in

PMID:
22825588
[PubMed - indexed for MEDLINE]
PMCID:
PMC3465767
Free PMC Article

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