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Circ Res. 2012 Jul 20;111(3):274-7. doi: 10.1161/CIRCRESAHA.112.275859.

Antibodies to PCSK9: a superior way to lower LDL cholesterol?


Lowering of LDL cholesterol, predominantly accomplished clinically by statins, is one of the key components of both the prevention and medical management of coronary atherosclerosis; however, additional or alternative cholesterol lowering agents are needed for patients who fail to achieve goals or have adverse effects on statins. Owing to relatively rapid translation of basic science research on a novel regulatory pathway of the LDL receptor by PCSK9, a new class of such drugs with a different mode of action, and potentially better tolerance and less off-target effects may be just over the horizon.

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