Send to:

Choose Destination
See comment in PubMed Commons below
Peptides. 2012 Sep;37(1):171-3. doi: 10.1016/j.peptides.2012.07.012. Epub 2012 Jul 20.

Neuroprotection of apelin and its signaling pathway.

Author information

  • 1Department of Neurology, Jining Medical University, Jining City, Shandong Province, PR China.


Apelin was initially isolated from bovine stomach and is an endogenous neuropeptide. It is a native ligand of the apelin receptor (APJ). Some research has found that apelin peptides alter blood pressure, feeding behavior, and pituitary hormone release. However, a new neuroprotective effect of apelin peptides was only recently discovered. This review summarizes the evidence of apelin-neuroprotection, which has the potential to cure acute and chronic neurological diseases.

Copyright © 2012 Elsevier Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk