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Cancer Lett. 2012 Dec 29;326(1):52-8. doi: 10.1016/j.canlet.2012.07.018. Epub 2012 Jul 20.

HPV infection in Brazilian patients with esophageal squamous cell carcinoma: interpopulational differences, lack of correlation with surrogate markers and clinicopathological parameters.

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  • 1Programa de Mecanismos de Carcinogênese Molecular, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.


The role of HPV in esophageal squamous cell carcinoma (ESCCs) is controversial. Therefore, we determined, through different methodologies, the prevalence of HPV in 264 ESCC samples from Brazil, and correlated it with the presence of surrogate markers and clinicopathological characteristics. HPV is present in 13% of ESCC, and with a 3-fold variation between high and medium incidence areas. Most HPV positive tumors were infected with HPV16, but this was not associated with p16 expression, TP53 mutation status, patient age, amount of tobacco or alcohol consumption, or overall survival. We conclude that HPV infection may not have a role in ESCC.

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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