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Cell. 2012 Jul 20;150(2):241-3. doi: 10.1016/j.cell.2012.07.004.

Transcription, splicing, and release: are we there yet?

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  • 1Laboratory of Molecular Biology and Immunology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA.


A systematic analysis of LPS-induced gene expression in macrophages by Bhatt et al. demonstrates that inflammatory responses are governed primarily at the level of transcription initiation. Unexpectedly, full-length nascent RNAs that contain introns appear to accumulate on chromatin, presumably to complete processing, prior to release of functional mRNA for export to the cytoplasm.

Copyright © 2012 Elsevier Inc. All rights reserved.

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