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Biochem Soc Trans. 2012 Aug;40(4):907-11. doi: 10.1042/BST20120042.

Non-coding RNAs in Saccharomyces cerevisiae: what is the function?

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  • 1Faculty of Life Sciences, University of Manchester, Manchester, UK.


New sequencing technologies and high-resolution microarray analysis have revealed genome-wide pervasive transcription in many eukaryotes, generating a large number of RNAs with no coding capacity. The focus of current debate is whether many of these ncRNAs (non-coding RNAs) are functional, and if so, what their function is. In this review, we describe recent discoveries in the field of ncRNAs in the yeast Saccharomyces cerevisiae. Newly identified ncRNAs in this budding yeast, their functions in gene regulation and possible mechanisms of action are discussed.

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