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Viruses. 2012 Jun;4(6):980-1010. doi: 10.3390/v4060980. Epub 2012 Jun 19.

Recent progress in studies of arterivirus- and coronavirus-host interactions.

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  • 1School of Biological Sciences, Nanyang Technological Sciences, 60 Nanyang Drive, Singapore 637551, Singapore.


Animal coronaviruses, such as infectious bronchitis virus (IBV), and arteriviruses, such as porcine reproductive and respiratory syndrome virus (PRRSV), are able to manifest highly contagious infections in their specific native hosts, thereby arising in critical economic damage to animal industries. This review discusses recent progress in studies of virus-host interactions during animal and human coronavirus and arterivirus infections, with emphasis on IBV-host cell interactions. These interactions may be directly involved in viral replication or lead to the alteration of certain signaling pathways, such as cell stress response and innate immunity, to facilitate viral replication and pathogenesis.


arterivirus; coronavirus; virus-host interactions

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