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World J Gastrointest Endosc. 2012 Jul 16;4(7):323-7. doi: 10.4253/wjge.v4.i7.323.

A study of the changes in the cause of peptic ulcer bleeding.

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  • 1Haruka Fujinami, Takahiko Kudo, Ayumu Hosokawsa, Kouhei Ogawa, Takako Miyazaki, Jun Nishikawa, Shinya Kajiura, Takayuki Ando, Akira Ueda, Toshiro Sugiyama, Department of Gastroenterology, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan.



To clarify the frequency of and changes in the cause of peptic ulcer bleeding.


This study retrospectively evaluated the out- and inpatients who underwent endoscopy between 2002 to 2008. The subjects were patients presenting with peptic ulcer bleeding. The details of these patients were obtained from their endoscopic reports and medical records.


The rates of Helicobacter pylori (H. pylori) infection were significantly low (P = 0.039), while the proportion of nonsteroidal antiinflammatory drugs (NSAIDs) users and vascular disease significantly increased over the period studied (P = 0.034 and P = 0.04, respectively). However, there was no significant difference in the proportion of low-dose aspirin users (P = 0.832).


It's found that the primary cause of peptic ulcer bleeding changed from H. pylori infection to use of NSAIDs over the 7-year period of study. It seems that the number of low-dose aspirin users has increased with the increase in the proportion of vascular disease. It is necessary to take measures to prevent peptic ulcer bleeding among NSAIDs and low dose aspirin users.


Gastroduodenal ulcer; Helicobacter pylori; Low-dose aspirin; Nonsteroidal antiinflammatory drugs; Peptic ulcer bleeding

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