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Curr Allergy Asthma Rep. 2012 Dec;12(6):641-9. doi: 10.1007/s11882-012-0284-1.

Anaphylaxis in children: current understanding and key issues in diagnosis and treatment.

Author information

  • Section of Allergy, Asthma and Immunology, Children's Mercy Hospital and Clinics, University of Missouri-Kansas City, Kansas City, MO 64108, USA. cdinakar@cmh.edu

Abstract

Anaphylaxis is a severe allergic reaction that is rapid in onset and may cause death. Since it is unpredictable and potentially fatal, prompt recognition and treatment are vital to maximize a positive outcome. The occurrence of anaphylaxis is increasing across all ages in the United States, with increased risk of worse outcome in teenagers/young adults and in those with comorbid conditions such as asthma. Gaps in the assessment of patient-specific risk factors, identification and prevention of triggers, recognition of signs/symptoms, and pharmacologic treatment of anaphylaxis have been identified at the physician and caregiver/patient level. A PubMed literature search (January 2000-December 2011) was conducted to identify publications on childhood anaphylaxis using the following terms: food allergy, food allergens, food hypersensitivity, epinephrine, epinephrine auto-injectors, anaphylactic triggers, and anaphylaxis. This review will critically appraise these key issues and highlight strategies that might result in improved management of anaphylaxis in children.

PMID:
22815131
[PubMed - indexed for MEDLINE]
PMCID:
PMC3492692
Free PMC Article
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