Negative regulators take center stage

Nat Immunol. 2012 Jul 19;13(8):719-20. doi: 10.1038/ni.2377.

Abstract

The transcription factor Aiolos is upregulated in T lymphocytes in a manner dependent on the transcription factors STAT3 and AhR and leads to epigenetic silencing of the gene encoding interleukin 2. This acts as a cell-intrinsic safeguard mechanism for the differentiation of helper T cells into the TH17 subset.

Publication types

  • Comment

MeSH terms

  • Animals
  • Ikaros Transcription Factor
  • Interleukin-2 / biosynthesis*
  • Lymphocyte Activation*
  • Th17 Cells / metabolism*
  • Trans-Activators / metabolism*

Substances

  • Ikzf3 protein, mouse
  • Interleukin-2
  • Trans-Activators
  • Ikaros Transcription Factor