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Dement Geriatr Cogn Disord. 2012;33(6):416-22. doi: 10.1159/000339367. Epub 2012 Jul 20.

Impact of beta-amyloid-specific florbetaben PET imaging on confidence in early diagnosis of Alzheimer's disease.

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  • 1Department of Psychiatry, Charit√©-Campus Benjamin Franklin, Berlin, Germany.

Erratum in

  • Dement Geriatr Cogn Disord. 2012;34(3-4):262.

Abstract

BACKGROUND:

Early diagnosis of Alzheimer's disease (AD) may be corroborated by imaging of beta-amyloid plaques using positron emission tomography (PET). Here, we performed an add-on questionnaire study to evaluate the relevance of florbetaben imaging (BAY 949172) in diagnosis and consecutive management of probable AD patients.

METHODS:

AD patients with a clinical diagnosis in accordance with the NINCDS-ADRDA criteria or controls were imaged using florbetaben. Referring physicians were asked on a voluntary basis about their confidence in initial diagnosis, significance of PET imaging results, and their anticipated consequences for future patient care.

RESULTS:

121 questionnaires for probable AD patients and 80 questionnaires for controls were evaluated. In 18% of patients who had initially received the diagnosis of probable AD, PET scans were rated negative, whereas in controls 18% of scans were positive. An increase in confidence in the initial diagnosis was frequently reported (80%). Imaging results had a significant impact on the intended patient care, as judged by the referring physicians; this was most prominent in those patients with a contradicting scan and/or a low confidence in the initial diagnosis.

CONCLUSION:

Florbetaben amyloid imaging increases the overall confidence in diagnosis of AD and may frequently influence clinical decisions and patient management.

Copyright © 2012 S. Karger AG, Basel.

PMID:
22814208
[PubMed - indexed for MEDLINE]
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