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Dement Geriatr Cogn Disord. 2012;33(6):400-9. doi: 10.1159/000339957. Epub 2012 Jul 17.

Central obesity, leptin and cognitive decline: the Sacramento Area Latino Study on Aging.

Author information

  • 1Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, USA. Adina.zekialhazzouri@ucsf.edu

Abstract

BACKGROUND/AIMS:

Central obesity is a risk factor for cognitive decline. Leptin is secreted by adipose tissue and has been associated with better cognitive function. Aging Mexican Americans have higher levels of obesity than non-Hispanic Whites, but no investigations examined the relationship between leptin and cognitive decline among them or the role of central obesity in this association.

METHODS:

We analyzed 1,480 dementia-free older Mexican Americans who were followed over 10 years. Cognitive function was assessed every 12-15 months with the Modified Mini Mental State Exam (3MSE) and the Spanish and English Verbal Learning Test (SEVLT).

RESULTS:

For females with a small waist circumference (≤35 inches), an interquartile range difference in leptin was associated with 35% less 3MSE errors and 22% less decline in the SEVLT score over 10 years. For males with a small waist circumference (≤40 inches), an interquartile range difference in leptin was associated with 44% less 3MSE errors and 30% less decline in the SEVLT score over 10 years. There was no association between leptin and cognitive decline among females or males with a large waist circumference.

CONCLUSION:

Leptin interacts with central obesity in shaping cognitive decline. Our findings provide valuable information about the effects of metabolic risk factors on cognitive function.

Copyright © 2012 S. Karger AG, Basel.

PMID:
22814127
[PubMed - indexed for MEDLINE]
PMCID:
PMC3483312
Free PMC Article
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