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Neurogastroenterol Motil. 2012 Dec;24(12):1142-5. doi: 10.1111/j.1365-2982.2012.01982.x. Epub 2012 Jul 20.

Comparison of calculations to estimate gastric emptying half-time of solids in humans.

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  • 1Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, College of Medicine, Rochester, MN 55905

Abstract

BACKGROUND:

Measuring solid gastric emptying (GE) at 4 h is used to identify gastroparesis. GE half-time (GE T(1/2) ) is useful to assess overall and early GE.

AIM:

To examine the validity of hourly imaging as a measurement of GE T(1/2) compared with estimates from more detailed imaging.

METHODS:

155 human subjects (99 female, 56 male) underwent scintigraphic GE of a solid-liquid meal. We calculated the GE T(1/2) using linear interpolation based on a full set of abdominal images obtained over 4 h, and the GE T(1/2) based on images at 1, 2, 3, and 4 after the meal with interpolation of data.

KEY RESULTS:

Differences in GE T(1/2) values (entire set of scan times compared with just the hourly scans) were small [overall median (5th, 95th percentiles) = -0.2[-7.5, 4.6] min] with slightly greater differences in males compared with females. The agreement between the two methods was very high [concordance correlation coefficient (CCC) (95% CI) = .993 (0.990, 0.995)] and a Bland-Altman plot indicated the variation in the results between the two methods did not change appreciably across the range of GE studied (within ±10 in for all but four subjects). Calculated GE T(1/2) values, omitting the 3-h data from the hourly measurements, were associated with similar high accuracy overall and for fast GE, but were less accurate with slow GE.

CONCLUSIONS & INFERENCES:

sults of GE T(1/2) solids, using hourly imaging over 4 , are accurate in the range 75-235 n which reflects the typical range of GE of solids in health and disease.

© 2012 Blackwell Publishing Ltd.

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