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Int J Med Sci. 2012;9(5):339-52. doi: 10.7150/ijms.4414. Epub 2012 Jul 1.

BioShuttle mobility in living cells studied with high-resolution FCS & CLSM methodologies.

Author information

  • 1Dept. of Imaging and Radiooncology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany. k.braun@dkfz.de

Abstract

With the increase in molecular diagnostics and patient-specific therapeutic approaches, the delivery and targeting of imaging molecules and pharmacologically active agents gain increasing importance. The ideal delivery system does not exist yet. The realization of two features is indispensable: first, a locally high concentration of target-specific diagnostic and therapeutic molecules; second, the broad development of effective and safe carrier systems. Here we characterize the transport properties of the peptide-based BioShuttle transporter using FFM and CLSM methods. The modular design of BioShuttle-based formulations results in a multi-faceted field of applications, also as a theranostic tool.

KEYWORDS:

BioShuttle; Confocal Laser Scanning Microscopy-CLSM; Drug Delivery; Fluorescence Correlation Spectroscopy-FCS; Fluorescence Fluctuation Microscopy-FFM; Ligation chemistry; Non-Viral Carrier Systems; Spinning Disc Microscopy-SDM.

PMID:
22811608
[PubMed - indexed for MEDLINE]
PMCID:
PMC3399214
Free PMC Article

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