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Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2006. doi: 10.1107/S1600536812017631. Epub 2012 Jun 13.

17α-Acet-oxy-11β-hy-droxy-6α-methyl-pregn-4-ene-3,20-dione.

Abstract

The title compound, C(24)H(34)O(5), a fungal-transformed metabolite of the injecta-ble contraceptive medroxyprogesterone acetate, consists of four fused rings (A, B, C and D; steroid labelling). Ring A exists in a half-chair conformation while trans-fused rings B and C adopt chair conformations. The five-membered ring D adopts an envelope conformation with the C atom bound to the methyl group at the flap. In the crystal, adjacent mol-ecules are linked by O-H⋯O and C-H⋯O hydrogen bonds, forming infinite chains along the a axis.

PMID:
22807835
[PubMed]
PMCID:
PMC3393278
Free PMC Article
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