Serglycin in health and diseases

Anat Rec (Hoboken). 2012 Sep;295(9):1415-20. doi: 10.1002/ar.22536. Epub 2012 Jul 16.

Abstract

Serglycin is a multifunctional molecule and one of the first proteoglycans to be cloned. In this manuscript, we examine the physiological roles of serglycin in immunity, hemostasis, cell growth, apoptosis, and reproduction. In addition, we review recent studies on the involvement of serglycin in various pathological conditions, including cancer, inflammatory diseases, and platelet disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Atherosclerosis / immunology
  • Atherosclerosis / metabolism
  • Atherosclerosis / pathology
  • Cell Enlargement
  • Hemostasis / physiology
  • Humans
  • Inflammation Mediators / blood
  • Inflammation Mediators / metabolism
  • Inflammation Mediators / physiology
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Proteoglycans / blood
  • Proteoglycans / physiology*
  • Reproduction / physiology
  • Vesicular Transport Proteins / blood
  • Vesicular Transport Proteins / physiology*

Substances

  • Inflammation Mediators
  • Proteoglycans
  • Vesicular Transport Proteins
  • serglycin