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Chem Commun (Camb). 2012 Sep 4;48(68):8496-8. doi: 10.1039/c2cc34289h. Epub 2012 Jul 18.

Silica-based gene reverse transfection: an upright nanosheet network for promoted DNA delivery to cells.

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  • 1World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan.


A method for substrate-mediated reverse gene transfection was developed using a silica film composed of an upright-sheet network. The silica film with a dense upright-sheet network shows approximately double higher transgene expression efficiency than that of solution-based transfection.

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