Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Transl Psychiatry. 2012 Jul 17;2:e140. doi: 10.1038/tp.2012.54.

The genetics of addiction-a translational perspective.

Author information

  • 1Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA. arpana@wustl.edu

Erratum in

  • Transl Psychiatry. 2012;2:e193.

Abstract

Addictions are serious and common psychiatric disorders, and are among the leading contributors to preventable death. This selective review outlines and highlights the need for a multi-method translational approach to genetic studies of these important conditions, including both licit (alcohol, nicotine) and illicit (cannabis, cocaine, opiates) drug addictions and the behavioral addiction of disordered gambling. First, we review existing knowledge from twin studies that indicates both the substantial heritability of substance-specific addictions and the genetic overlap across addiction to different substances. Next, we discuss the limited number of candidate genes which have shown consistent replication, and the implications of emerging genomewide association findings for the genetic architecture of addictions. Finally, we review the utility of extensions to existing methods such as novel phenotyping, including the use of endophenotypes, biomarkers and neuroimaging outcomes; emerging methods for identifying alternative sources of genetic variation and accompanying statistical methodologies to interpret them; the role of gene-environment interplay; and importantly, the potential role of genetic variation in suggesting new alternatives for treatment of addictions.

PMID:
22806211
[PubMed - indexed for MEDLINE]
PMCID:
PMC3410620
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk