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BMC Biol. 2012 Jul 17;10:61. doi: 10.1186/1741-7007-10-61.

Shedding light on local kinase activation.

Author information

  • 1Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine,1959 Pacific Ave, NE, Seattle, WA 98195 USA. scottjdw@u.washington.edu

Abstract

Phosphorylation is the predominant language of cell signaling. And, as with any common language, an abundance of dialects has evolved to convey complex information. We discuss here how biosensors are being used to decode this language, affording an unprecedented glimpse into spatio-temporal patterns of protein phosphorylation events within the cell.

PMID:
22805055
[PubMed - indexed for MEDLINE]
PMCID:
PMC3398854
Free PMC Article
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