Acute microbiologically negative hypoxic interstitial pneumonia on HAART: Immune Reconstitution Inflammatory Syndrome unmasking Pneumocystis jiroveci infection with an atypical presentation

S Sovaila; A de Raigniac; C Picard; O Taulera; C Lascoux-Combe; D Sereni; A Bourgarit

Acute microbiologically negative hypoxic interstitial pneumonia on HAART: Immune Reconstitution Inflammatory Syndrome unmasking Pneumocystis jiroveci infection with an atypical presentation

J Med Life. 2012 Jun 12;5(2):189-91. Epub 2012 Jun 18.

Authors

S Sovaila¹, A de Raigniac, C Picard, O Taulera, C Lascoux-Combe, D Sereni, A Bourgarit

Affiliation

¹ Department of Internal Medicine, Saint-Louis Hospital, AP-HP, Paris, France.

PMID: 22802889
PMCID: PMC3391890

Abstract

Highly active antiretroviral therapy for AIDS sometimes engenders inflammatory manifestations resulting from an inappropriate and unbalanced immune-system restoration, called Immune Reconstitution inflammatory Syndrome, which, in turn, can unmask a subclinical infection/pathology. Despite our patient's evident syndrome, the atypical clinical, microbiologic and radiologic feature of Pneumocystis pneumonia made its diagnosis difficult.

Keywords: HAART; HIV; Pneumocystis jiroveci; immune restoration inflammatory syndrome (IRIS); unmasking.

Publication types

Case Reports

MeSH terms

Acute Disease
Adult
Antiretroviral Therapy, Highly Active / adverse effects*
Female
Humans
Hypoxia / diagnostic imaging
Hypoxia / etiology*
Hypoxia / microbiology
Immune Reconstitution Inflammatory Syndrome / diagnostic imaging
Immune Reconstitution Inflammatory Syndrome / etiology*
Lung Diseases, Interstitial / diagnostic imaging
Lung Diseases, Interstitial / etiology*
Lung Diseases, Interstitial / microbiology
Pneumocystis carinii / physiology*
Pneumonia, Pneumocystis / diagnostic imaging
Pneumonia, Pneumocystis / etiology*
Pneumonia, Pneumocystis / microbiology
Radiographic Image Enhancement
Tomography, X-Ray Computed