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Int J Nanomedicine. 2012;7:3099-109. doi: 10.2147/IJN.S30934. Epub 2012 Jun 29.

Concentration-dependent effects of fullerenol on cultured hippocampal neuron viability.

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  • 1CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, University of Science and Technology of China, Hefei, People’s Republic of China.

Abstract

BACKGROUND:

Recent studies have shown that the biological actions and toxicity of the water-soluble compound, polyhydroxyfullerene (fullerenol), are related to the concentrations present at a particular site of action. This study investigated the effects of different concentrations of fullerenol on cultured rat hippocampal neurons.

METHODS AND RESULTS:

Fullerenol at low concentrations significantly enhanced hippocampal neuron viability as tested by MTT assay and Hoechst 33342/propidium iodide double stain detection. At high concentrations, fullerenol induced apoptosis confirmed by Comet assay and assessment of caspase proteins.

CONCLUSION:

These findings suggest that fullerenol promotes cell death and protects against cell damage, depending on the concentration present. The concentration-dependent effects of fullerenol were mainly due to its influence on the reduction-oxidation pathway.

KEYWORDS:

fullerenol; hippocampal neuron; nanomaterial; neuroprotection; neurotoxicity

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