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Genes Dev. 2012 Jul 15;26(14):1520-6. doi: 10.1101/gad.198051.112.

Tyrosyl phosphorylation toggles a Runx1 switch.

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  • 1Campbell Family Cancer Research Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada.

Abstract

The Runx1 transcription factor is post-translationally modified by seryl/threonyl phosphorylation, acetylation, and methylation that control its interactions with transcription factor partners and epigenetic coregulators. In this issue of Genes & Development, Huang and colleagues (pp. 1587-1601) describe how the regulation of Runx1 tyrosyl phosphorylation by Src family kinases and the Shp2 phosphatase toggle Runx1's interactions between different coregulatory molecules.

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PMID:
22802526
[PubMed - indexed for MEDLINE]
PMCID:
PMC3404380
Free PMC Article

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