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Microbes Infect. 2012 Nov;14(14):1293-300. doi: 10.1016/j.micinf.2012.07.005. Epub 2012 Jul 16.

The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses.

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  • 1Dept. of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland. fabio.martinon@unil.ch

Abstract

Many inflammatory and infectious diseases are characterized by the activation of signaling pathways steaming from the endoplasmic reticulum (ER). These pathways, primarily associated with loss of ER homeostasis, are emerging as key regulators of inflammation and infection. Recent advances shed light on the mechanisms linking ER-stress and immune responses.

Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

[PubMed - indexed for MEDLINE]
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