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Pharm Res. 2013 Jan;30(1):25-31. doi: 10.1007/s11095-012-0825-2. Epub 2012 Jul 14.

Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N,N-dodecyl,methyl-polyethylenimine.

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  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.

Abstract

PURPOSE:

To explore surface-immobilized and suspended modalities of the hydrophobic polycation N,N-dodecyl,methyl-polyethylenimine (DMPEI) for the ability to reduce viral infectivity in aqueous solutions containing herpes simplex viruses (HSVs) 1 and 2.

METHODS:

Surface-immobilized (coated onto surfaces) and suspended DMPEI were incubated with aqueous solutions containing HSV-1 or -2 to measure the antiviral effect of the hydrophobic polycation's formulations on HSVs.

RESULTS:

DMPEI coated on either polyethylene slides or male latex condoms dramatically decreases infectivity in solutions containing HSV-1 or -2. Moreover, DMPEI suspended in aqueous solution markedly reduces the infectious titer of these HSVs.

CONCLUSION:

Our results suggest potential uses of DMPEI for both prophylaxis (in the form of coated condoms) and treatment (as a topical suspension) for HSV infections.

PMID:
22798261
[PubMed - indexed for MEDLINE]
PMCID:
PMC3583229
Free PMC Article
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