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Curr Treat Options Neurol. 2012 Aug;14(4):369-80. doi: 10.1007/s11940-012-0185-6.

Recent innovations in the management of low-grade gliomas.

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  • 1Department of Neurology/Neurosurgery, Wexner Medical Center at The Ohio State University Medical Center, 456 West 10th Avenue, Suite 1200, Columbus, OH, 43210, USA, Shaheryar.Hafeez@osumc.edu.



Advancement in the understanding of biologic mechanisms of low-grade glioma pathophysiology has allowed the modern era of patient-specific genetic profiling, molecular biology, and neuroimaging to design new methods of surgery, radiation, and chemotherapy in hopes of preventing malignant transformation and improving outcomes. Recent innovations in the understanding of MGMT promoter methylation, IDH1 and IDH2 mutations, temozolomide chemotherapy, vascular monoclonal antibody treatment, use of radiation therapy, choice of antiepileptic drugs, surgical resection, and neuroimaging of low-grade gliomas are reviewed.

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