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Dement Geriatr Cogn Disord. 2012;33(5):354-60. doi: 10.1159/000339670. Epub 2012 Jul 10.

Activities of daily living in progressive non-fluent aphasia, logopenic progressive aphasia and Alzheimer's disease.

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  • 1Neuroscience Research Australia, Sydney, Australia.



This study examined functional changes in progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (LPA) and Alzheimer's disease (AD) and the association between function, cognition and behaviour.


59 patients were assessed with the Disability Assessment of Dementia (DAD), Addenbrooke's Cognitive Examination Revised (ACE-R) and the Cambridge Behavioural Inventory Revised (CBI-R).


No differences between groups in basic and instrumental activities of daily living (ADLs), and total ACE-R scores were found; there were correlations between total DAD and ACE-R scores for PNFA and LPA. Over 12 months, PNFA showed the marked decline of basic ADLs, whereas all three groups showed marked decline of instrumental ADLs.


PNFA, LPA and AD appear functionally similar when matched for disease duration. The rate of decline of ADLs depends, however, on disease diagnosis.

Copyright © 2012 S. Karger AG, Basel.

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