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J Neuroradiol. 2013 May;40(2):89-93. doi: 10.1016/j.neurad.2012.04.001. Epub 2012 Jul 12.

Reduced white matter integrity in primary open-angle glaucoma: a DTI study using tract-based spatial statistics.

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  • 1Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, PR China. pglu912@126.com

Abstract

BACKGROUND AND PURPOSE:

The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis.

METHODS:

Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE).

RESULTS:

Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected).

CONCLUSION:

The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.

Copyright © 2012 Elsevier Masson SAS. All rights reserved.

PMID:
22796270
[PubMed - indexed for MEDLINE]
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