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J Renin Angiotensin Aldosterone Syst. 2013 Dec;14(4):354-9. doi: 10.1177/1470320312452029. Epub 2012 Jul 12.

AGT gene polymorphisms (M235T, T174M) are associated with coronary heart disease in a Chinese population.

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  • 11Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, China.

Abstract

OBJECTIVE:

The angiotensinogen (AGT) gene has been shown to be involved in the development of coronary heart disease (CHD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to clarify the associations between AGT polymorphisms and CHD risk among the Chinese population.

METHODS:

Published literature from PubMed, the China National Knowledge Infrastructure and Wanfang Data were searched. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a fixed- or random-effects model.

RESULTS:

Fourteen studies (2540 cases and 2173 controls) for M235T polymorphism and five studies (655 cases and 815 controls) for T174M polymorphism were included in the meta-analyses. The results showed that M235T polymorphism was significantly associated with CHD risk under a recessive model (OR=1.65, 95% CI 1.22-2.25). There was also significant association between T174M polymorphism and CHD risk under a homogeneous co-dominant model (OR= 4.20, 95% CI 1.90-9.29) and a recessive model (OR=4.15, 95% CI 1.88-9.15). Further sensitivity analyses confirmed the significant association.

CONCLUSIONS:

The meta-analyses indicated the significant associations of two AGT polymorphisms (M235T, T174M) with CHD risk in the Chinese population.

KEYWORDS:

Angiotensinogen gene; Chinese; coronary heart disease; meta-analysis; polymorphism

PMID:
22791700
[PubMed - indexed for MEDLINE]
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