Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
J Virol. 2012 Oct;86(19):10293-301. doi: 10.1128/JVI.01131-12. Epub 2012 Jul 11.

NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challenge.

Author information

  • 1Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA.


Immunological changes associated with age contribute to the high rates of influenza virus morbidity and mortality in the elderly. Compounding this problem, aged individuals do not respond to vaccination as well as younger, healthy adults. Efforts to increase protection to this demographic group are of utmost importance, as the proportion of the population above the age of 65 is projected to increase in the coming decade. Using a live influenza virus with a truncated nonstructural protein 1 (NS1), we are able to stimulate cellular and humoral immune responses of aged mice comparable to levels seen in young mice. Impressively, a single vaccination provided protection following stringent lethal challenge in aged mice.

[PubMed - indexed for MEDLINE]
Free PMC Article

Images from this publication.See all images (6)Free text

Fig 1
Fig 2
Fig 3
Fig 4
Fig 5
Fig 6
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk