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Cell Res. 2012 Nov;22(11):1524-6. doi: 10.1038/cr.2012.98. Epub 2012 Jun 26.

Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation.

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  • 1Program in Gene Function & Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA.


One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.

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