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Nanotoxicology. 2013 Sep;7(6):1143-51. doi: 10.3109/17435390.2012.711862. Epub 2012 Aug 20.

Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro.

Author information

  • 1Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.

Abstract

The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials.

PMID:
22783847
[PubMed - indexed for MEDLINE]
PMCID:
PMC3737271
Free PMC Article
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