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Mycobiology. 2011 Dec;39(4):243-8. doi: 10.5941/MYCO.2011.39.4.243. Epub 2011 Dec 7.

The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi.

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  • 1Public Health Research Institute, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA.


The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 ubiquitin ligases that transfer ubiquitin to the substrates that are subjected to degradation in the 26S proteasome. The Skp1, Cullin, F-box protein (SCF) E3 ligases are the largest E3 gene family, in which the F-box protein is the key component to determine substrate specificity. Although the SCF E3 ligase and its F-box proteins have been extensively studied in the model yeast Saccharomyces cerevisiae, only limited studies have been reported on the role of F-box proteins in other fungi. Recently, a number of studies revealed that F-box proteins are required for fungal pathogenicity. In this communication, we review the current understanding of F-box proteins in pathogenic fungi.


Cryptococcus neoformans; E3 ligase; F-box; Fungi; Virulence

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