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World J Gastroenterol. 2012 Jul 7;18(25):3296-302. doi: 10.3748/wjg.v18.i25.3296.

Expression and significance of homeodomain protein Cdx2 in gastric carcinoma and precancerous lesions.

Author information

  • 1Department of Pathology, Basic Medical College, Anhui Medical University, Hefei 230032, Anhui Province, China. rongqincn@yahoo.com.cn

Abstract

AIM:

To investigate the expression and significance of caudal-related homeobox transcription factor (Cdx2) in gastric carcinoma (GC) and precancerous lesions.

METHODS:

The expression of Cdx2 in GC, precancerous lesions and normal gastric mucosa were detected using immunohistochemical method. Hematoxylin and eosin staining, alcian blue/periodic acid-schiff and high iron diamine/alcian blue staining were used to classify intestinal metaplasia (IM) and GC.

RESULTS:

Cdx2 was not detected in normal gastric mucosa. Cdx2 expression was detected in 87.1% (101/116) of IM, 50% (36/72) of dysplasia and 48.2% (41/85) of GC. The Cdx2-expressing cells in IM were more prevalent than in dysplasia and carcinoma (P < 0.05). There was no relationship between Cdx2 expression and the classification of IM or the degree of dysplasia. Expression of Cdx2 was significantly higher in intestinal-type carcinoma than in diffuse and mixed-type carcinoma (P < 0.05). Positive expression of Cdx2 was mainly found in moderately to well differentiated GC. There was a negative association between nuclear Cdx2 expression and lymph node metastasis and tumor, nodes, metastasis stage of GC (P < 0.05). The patients with Cdx2-positive expression showed a higher survival rate than those with Cdx2-negative expression (P = 0.038). Multivariate analysis revealed that the expression of Cdx2 and lymph node metastasis were independent prognostic indicators of GC (P < 0.05).

CONCLUSION:

Cdx2 may be closely related to IM and the intestinal-type GC and implicate better biological behavior and outcome. Cdx2 is useful for predicting the prognosis of GC.

KEYWORDS:

Caudal-related homeobox transcription factor; Dysplasia; Immunohistochemistry; Intestinal metaplasia; Stomach neoplasm

PMID:
22783055
[PubMed - indexed for MEDLINE]
PMCID:
PMC3391768
Free PMC Article
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