The structure of cardiac glycogen in healthy mice

Int J Biol Macromol. 2012 Dec;51(5):887-91. doi: 10.1016/j.ijbiomac.2012.06.037. Epub 2012 Jul 7.

Abstract

Transmission electron micrographs of glycogen extracted from healthy mouse hearts reveal aggregate structures around 133 nm in diameter. These structures are similar to, but on average somewhat smaller than, the α-particles of glycogen found in mammalian liver. Like the larger liver glycogens, these new particles in cardiac tissue appear to be aggregates of β-particles. Free β-particles are also present in liver, and are the only type of particle seen in skeletal muscle. They have diameters from 20 to 50 nm. We discuss the number distributions of glycogen particle diameters and the implications for the structure-function relationship of glycogens in these tissues. We point out the possible implications for the study of glycogen storage diseases, and of non-insulin dependent diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Glycogen / chemistry*
  • Health*
  • Mice
  • Myocardium / chemistry*
  • Particle Size

Substances

  • Glycogen