Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Gastroenterol. 2012 Sep;107(9):1399-406. doi: 10.1038/ajg.2012.196. Epub 2012 Jul 10.

A prospective study of cigarette smoking and the risk of inflammatory bowel disease in women.

Author information

  • 1Division of Gastroenterology and Nutrition, Children's Hospital Boston, Boston, Massachusetts 02115, USA. leslie.higuchi@childrens.harvard.edu

Abstract

OBJECTIVES:

Long-term data on the influence of cigarette smoking, especially cessation, on the risk of Crohn's disease (CD) and ulcerative colitis (UC) are limited.

METHODS:

We conducted a prospective study of 229,111 women in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHS II). Biennially, we collected updated data on cigarette smoking, other risk factors, and diagnoses of CD or UC confirmed by medical record review.

RESULTS:

Over 32 years in NHS and 18 years in NHS II, we documented 336 incident cases of CD and 400 incident cases of UC. Compared with never smokers, the multivariate hazard ratio (HR) of CD was 1.90 (95% confidence interval (CI), 1.42-2.53) among current smokers and 1.35 (95% CI, 1.05-1.73) among former smokers. Increasing pack-years was associated with increasing risk of CD (Ptrend < 0.0001), whereas smoking cessation was associated with an attenuation of risk. By contrast, the multivariate HR of UC was 0.86 (95% CI, 0.61-1.20) among current smokers and 1.56 (95% CI, 1.26-1.93) among former smokers. The risk of UC was significantly increased within 2-5 years of smoking cessation (HR, 3.06; 95% CI, 2.00-4.67) and remained persistently elevated over 20 years.

CONCLUSIONS:

Current smoking is associated with an increased risk of CD, but not UC. By contrast, former smoking is associated with an increased risk of UC, with risk persisting over two decades after cessation.

PMID:
22777340
[PubMed - indexed for MEDLINE]
PMCID:
PMC3667663
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk