Repopulation of ganciclovir-resistant cytomegalovirus by wild-type virus

W Lawrence Drew; Catherine Liu

doi:10.1111/j.1399-0012.2012.01681.x

Repopulation of ganciclovir-resistant cytomegalovirus by wild-type virus

Clin Transplant. 2012 Nov-Dec;26(6):949-52. doi: 10.1111/j.1399-0012.2012.01681.x. Epub 2012 Jul 9.

Authors

W Lawrence Drew¹, Catherine Liu

Affiliation

¹ Department of Laboratory Medicine and Medicine, University of California, San Francisco, San Francisco, CA 94143-0654, USA.

PMID: 22774759
DOI: 10.1111/j.1399-0012.2012.01681.x

Abstract

We report a patient in whom ganciclovir (GCV)-resistant cytomegalovirus (CMV) was replaced by wild-type virus after discontinuation of GCV/valganciclovir and review other similar cases. Repopulation by wild-type virus may occur soon after discontinuation and may be fostered by discontinuing GCV altogether rather than continuing it in combination with foscarnet when treating patients with GCV-resistant CMV disease.

Publication types

Case Reports

MeSH terms

Antiviral Agents / therapeutic use*
Cytomegalovirus / pathogenicity
Cytomegalovirus Infections / drug therapy
Cytomegalovirus Infections / surgery
Cytomegalovirus Infections / virology*
Drug Resistance, Viral*
Drug Therapy, Combination
Female
Ganciclovir / analogs & derivatives*
Ganciclovir / therapeutic use*
Humans
Lung Transplantation / adverse effects*
Middle Aged
Prognosis
Pulmonary Fibrosis / complications
Pulmonary Fibrosis / surgery
Pulmonary Fibrosis / virology*
Valganciclovir

Substances

Antiviral Agents
Valganciclovir
Ganciclovir