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Pediatr Infect Dis J. 2012 Nov;31(11):1155-7. doi: 10.1097/INF.0b013e318267ef6a.

Rash, hepatotoxicity and hyperbilirubinemia among Kenyan infants born to HIV-infected women receiving triple-antiretroviral drugs for the prevention of mother-to-child HIV transmission.

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  • 1Epidemic Intelligence Service and ‚ĆDivision of HIV/AIDS Prevention, CDC, Atlanta, GA, USA. iyo4@cdc.gov

Abstract

We compared adverse events among breast-feeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy, including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in the risk of rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breast-feeding are viable options where alternatives to breast milk are not safe, affordable or feasible.

PMID:
22772167
[PubMed - indexed for MEDLINE]
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