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Chimerism. 2012 Apr-Jun;3(2):40-2. doi: 10.4161/chim.20726. Epub 2012 Apr 1.

Conditioning with α-emitter based radioimmunotherapy in canine allogeneic hematopoietic cell transplantation.

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  • 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.


With the introduction of nonmyeloablative conditioning, hematopoietic cell transplantation (HCT) has become a viable treatment option for patients who due to age or comorbidities are ineligible for high dose conditioning. However, relapse and toxicities are still major problems in HCT. Radioimmunotherapy (RIT)-based conditioning is a promising approach that has the ability to specifically target radiation to hematopoietic cells. The most widely investigated isotopes are the β-emitters, but because of long path lengths and low linear energy transfer, α-emitters which have more favorable physical characteristics, might prove to be a better alternative. In the current study we have investigated the efficacy and safety of α-emitter based RIT as the only form of conditioning in a preclinical model of canine allogeneic HCT.

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