Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Transcription. 2012 Jul-Aug;3(4):181-6. doi: 10.4161/trns.20720. Epub 2012 Jul 1.

Transcription regulation by distal enhancers: who's in the loop?

Author information

  • 1Department of Cell Biology; Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.

PMID:
22771987
[PubMed - indexed for MEDLINE]
PMCID:
PMC3654767
Free PMC Article

Images from this publication.See all images (2)Free text

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Landes Bioscience Icon for PubMed Central
    Loading ...
    Write to the Help Desk