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Transcription. 2012 May-Jun;3(3):110-4. doi: 10.4161/trns.19840.

Selective role of Mediator tail module in the transcription of highly regulated genes in yeast.

Author information

  • 1Laboratory of Molecular Genetics, Wadsworth Center, New York State Department of Health, Albany, NY, USA. sansari@wadsworth.org

Abstract

The tail module subunits of Mediator complex are targets of activators both in yeast and metazoans. Here we discuss recent evidence from studies in yeast for tail module specificity for SAGA-dependent, TATA-containing genes including highly regulated stress response genes, and for independent recruitment and function of the tail module.

PMID:
22771944
[PubMed - indexed for MEDLINE]
PMCID:
PMC3616079
Free PMC Article

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