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Int J Pharm. 2012 Oct 15;436(1-2):32-40. doi: 10.1016/j.ijpharm.2012.06.057. Epub 2012 Jul 5.

Investigation of formulation factors affecting in vitro and in vivo characteristics of a galantamine transdermal system.

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  • 1School of Pharmacy, Sungkyunkwan University, Republic of Korea.

Abstract

Because of low treatment compliance with the Alzheimer disease patients, there have been clinical needs for the alternative administration route to effective and well-tolerated approaches of galantamine (Small and Dubois, 2007). In this study, drug-in-adhesive transdermal patches with galantamine were prepared and evaluated in vitro and in vivo. The in vitro permeation studies indicated that DT-2510 was the most suitable pressure-sensitive-adhesive and oleic acid was the most promising enhancer for galantamine drug-in-adhesive patch. The optimized galantamine drug-in-adhesive patch could be physicochemically stable for 28 days at 40 °C/75% RH. The in vivo studies of the optimized galantamine drug-in-adhesive patch showed high absolute bioavailability of around 80% and sustained effect on the drug plasma levels for 24 h. The in vitro and in vivo studies of galantamine drug-in-adhesive patches with different pressure-sensitive-adhesive functional groups showed a strong correlation between the skin permeation rate and the area under the curve. The results suggest that the transdermal application of galantamine drug-in-adhesive patches might be the alternative dosage form to have good efficacy and tolerability for the treatment of Alzheimer disease.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
22771734
[PubMed - indexed for MEDLINE]
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