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Life Sci. 2012 Aug 21;91(3-4):77-82. doi: 10.1016/j.lfs.2012.06.022. Epub 2012 Jul 4.

Immunosuppressant FK506: focusing on neuroprotective effects following brain and spinal cord injury.

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  • 1Institute of Neurobiology, Center of Excellence, Slovak Academy of Sciences, Košice, Slovak Republic. sagan@saske.sk

Abstract

The secondary damage that follows central nervous system (CNS) injury is a target for neuroprotective agents aimed at tissue and function sparing. FK506, a clinically used immunosuppressant, acts neuroprotectively in rat models of brain and spinal cord injury and ischemia. Evidence of in vivo experimental studies highlights the neuroprotective role of FK506 by its direct impact on various cell populations within the CNS. The participation of FK506 in modulation of post-traumatic inflammatory processes is a further potential aspect involved in CNS neuroprotection. In this review we provide an overview of the current laboratory research focusing on the multiple effects of FK506 on neuroprotection following CNS injury.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
22771695
[PubMed - indexed for MEDLINE]
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