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Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 2;47:135-9. doi: 10.1016/j.pnpbp.2012.06.021. Epub 2012 Jul 4.

Can bariatric surgery reduce risk of Alzheimer's disease?

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  • 1Department of Psychology, University of Alabama, Tuscaloosa, AL, 35487, USA. Electronic address:


Recent studies demonstrate that obesity is independently associated with poor neurocognitive outcomes, including cognitive impairment, increased risk for dementia, and regional alterations in brain structure. Bariatric surgery is an effective treatment for obesity and initial findings suggest that it may result in cognitive improvements. The current paper reviews and integrates recent research in this area, with a focus on potential mediators and moderators of neuropsychological outcome in bariatric surgery patients, including anesthetic and nutritional complications, and proposes novel avenues for continued study in this area.

Copyright © 2012 Elsevier Inc. All rights reserved.


Alzheimer's disease; BMI; Bariatric surgery; Cognitive function; Obesity; body mass index

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