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Cell Stem Cell. 2012 Jul 6;11(1):9-15. doi: 10.1016/j.stem.2012.06.012.

Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.

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  • 1Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. aw512@cam.ac.uk


Human somatic cells can be reprogrammed into induced pluripotent stem cells (hiPSCs) with wide lineage differentiation potential in culture. However, reprogramming and long-term culture can also induce abnormalities in these pluripotent cells. This minireview discusses recent studies that have identified changes in imprinted gene expression and erosion of X chromosome inactivation in female hiPSCs and how understanding the sources and consequences of epigenetic variability in hiPSCs will impact disease modeling and clinical application in the future.

Copyright © 2012 Elsevier Inc. All rights reserved.

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