Cell Stem Cell. 2012 Jul 6;11(1):3-4. doi: 10.1016/j.stem.2012.06.014.

Reprogramming a broken heart.

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Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 01238, USA.

Abstract

Fibrosis resulting from cardiac injury presents a major challenge to restoring heart function after myocardial infarction. Two recent papers in Nature report successful in vivo reprogramming of fibroblasts to cardiomyocytes in injured mouse hearts (Qian et al., 2012; Song et al., 2012), resulting in improved cardiac function and reduced scar formation.

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In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. [Nature. 2012]
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. Nature. 2012 May 31; 485(7400):593-8.

PMID:: 22770235; [PubMed]

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Reprogramming a broken heart.
Reprogramming a broken heart.
Cell Stem Cell. 2012 Jul 6 ;11(1):3-4. doi: 10.1016/j.stem.2012.06.014.

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Reprogramming a broken heart.

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