Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Pediatr Endocrinol Metab. 2012;25(3-4):301-5.

Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns.

Author information

  • 1Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. kelli-ryckman@uiowa.edu

Abstract

Nationally, newborn screening programs use 17-hydroxyprogesterone (17-OHP) as the biomarker to detect the rare but potentially fatal inherited disease, congenital adrenal hyperplasia. However, this biomarker is highly variable, with a high false-positive rate of detection, particularly in neonates born preterm. Several studies have examined various clinical and genetic factors to explain the variability of 17-OHP in preterm infants. The purpose of this study was to replicate previous clinical and genetic associations with 17-OHP in a well-characterized cohort of 762 preterm infants. We replicated previous findings that respiratory distress syndrome (p = 2 x 10(-3)) is associated with higher 17-OHP. Higher 17-OHP and false positives were significantly associated with lower gestational age and birth weight, as previously reported. Incorporating gestational age and birth weight together decreases the false-positive rate.

PMID:
22768660
[PubMed - indexed for MEDLINE]
PMCID:
PMC3552557
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk