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Eye (Lond). 2012 Oct;26(10):1295-301. doi: 10.1038/eye.2012.137. Epub 2012 Jul 6.

Estimating quality-adjusted life years from patient-reported visual functioning.

Author information

  • 1Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Leeds LS2 9LJ, UK. c.browne@leeds.ac.uk

Abstract

PURPOSE:

Glaucoma is an important disease, the impacts of which on vision have been shown to have implications for patients' health-related quality of life (HRQoL). The primary aim of this study is to estimate a mapping algorithm to predict EQ-5D and SF-6D utility values based on the vision-specific measure, the 25-item Visual Functioning Questionnaire (VFQ-25), as well as the clinical measures of visual function, that is, integrated visual field, visual acuity, and contrast sensitivity.

METHODS:

Ordinary least squares (OLS), Tobit, and censored least absolute deviations were compared using data taken from the Moorfields Eye Hospital in London, to assess mapping functions to predict the EQ-5D and SF-6D from the VFQ-25, and tests of visual function. These models were compared using root mean square error (RMSE), R(2), and mean absolute error (MAE).

RESULTS:

OLS was the best-performing model of the three compared, as this produced the lowest RMSE and MAE, and the highest R(2).

CONCLUSIONS:

The models provided initial algorithms to convert the VFQ-25 to the EQ-5D and SF-6D. Further analysis would be needed to validate the models or algorithms.

PMID:
22766537
[PubMed - indexed for MEDLINE]
PMCID:
PMC3470057
Free PMC Article
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