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PLoS One. 2012;7(6):e39410. doi: 10.1371/journal.pone.0039410. Epub 2012 Jun 25.

Influence of age, circadian and homeostatic processes on inhibitory motor control: a Go/Nogo task study.

Author information

  • 1CNRS USR 3413 SANPSY, Sleep, Attention and NeuroPSYchiatrie, Université de Bordeaux, Bordeaux, France. patricia.sagaspe@gmail.com

Abstract

INTRODUCTION:

The contribution of circadian system and sleep pressure influences on executive performance as a function of age has never been studied. The aim of our study was to determine the age-related evolution of inhibitory motor control (i.e., ability to suppress a prepotent motor response) and sustained attention under controlled high or low sleep pressure conditions.

METHODS:

14 healthy young males (mean age = 23 ± 2.7; 20-29 years) and 11 healthy older males (mean age = 68 ± 1.4; 66-70 years) were recruited. The volunteers were placed for 40 hours in "constant routine". In the "Sleep Deprivation SD" condition, the volunteer was kept awake for 40 hours to obtain a high sleep pressure condition interacting with the circadian process. In the "NAP" condition, the volunteer adopted a short wake/sleep cycle (150/75 min) resulting in a low sleep pressure condition to counteract the homeostatic pressure and investigate the circadian process. Performances were evaluated by a simple reaction time task and a Go/Nogo task repeated every 3H45.

RESULTS:

In the SD condition, inhibitory motor control (i.e., ability to inhibit an inappropriate response) was impaired by extended wakefulness equally in both age groups (P<.01). Sustained attention (i.e. ability to respond accurately to appropriate stimuli) on the executive task decreased under sleep deprivation in both groups, and even more in young participants (P<.05). In the NAP condition, age did not influence the time course of inhibitory motor control or sustained attention. In the SD and NAP conditions, older participants had a less fluctuating reaction time performance across time of day than young participants (P<.001).

CONCLUSION:

Aging could be a protective factor against the effects of extended wakefulness especially on sustained attention failures due to an attenuation of sleep pressure with duration of time awake.

PMID:
22761784
[PubMed - indexed for MEDLINE]
PMCID:
PMC3382614
Free PMC Article

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